Network Pharmacological Evaluation of Glycyrrhiza glabra for its Activity against Neuropathic Pain

Glycyrrhiza glabra (licorice), is used for therapeutic purposes since ages. Neuropathic pain a disease with complex pathophysiology, involving dysfunction in multiple ion channel receptors such as sodium, transient receptor potential channels, neurotransmitters, inflammatory mediators and reactive oxygen species. Network pharmacology newly emerging approach dealing understanding mechanism of actions druggable molecules the targets. This suitable to deal Ayush based medicines extracts containing many bioactives, acting on The aim present study construct network licorice predict its against neuropathic pain. Various knowledge databases were collecting information regarding their targets genes associated these or pathophysiology These include drusenoid pigment epithelial detachment, PubMed, Google scholar, PubChem, Binding Database, Kyoto encyclopedia genomes, DisGeNET target database. was constructed using Cytoscape3.7.2. 19 bioactive shortlisted by extensive search having humans rats Database. searched association Targets shown be part pathways pain, helping action bioactive. Hence, this can prove helpful modern pharmacological research.